RHODANINE BASED MOLECULES ARE ONE OF THE MOST IMPORTANT HETEROCYCLES THAT ARE INTERESTED FORTHEIR PHARMACOLOGICAL ACTIVITY, WHICH INCLUDE ANTIMICROBIAL, ANTIVIRAL, AND ANTIDIABETIC.1 ANINTERESTING GROUP OF RHODANINES ARE 2, 2’ -DITHIOXO- [5, 5’ ] BITHIAZOLIDINYLIDENE-4, 4’ -DIONE(BIRHODANINE) DERIVATIVES…..

THIOAMIDES ARE ESSENTIAL BUILDING BLOCKS FOR THE PREPARATION OF A NUMBER OF BIOLOGICALLY RELEVANT HETEROCYCLIC SCAFFOLDS AND MANY DIFFERENT METHODS FOR THEIR PREPARATION HAVE BEEN REPORTED. IN THIS REGARD, THE THREE-COMPONENT WILLGERODT-KINDLER REACTION IS WELL KNOWN AS AN IMPORTANT METHOD FOR....

THIOXANTHONE DERIVATIVES ARE potENTIAL ANTI-CANCER DRUGS AND THEY ARE AN IMPORTANT CLASS OF MOLECULES AND ARE A COMMON HETEROCYCLIC SCAFFOLD IN BIOLOGICALLY ACTIVE AND MEDICINALLY SIGNIFICANT COMPOUNDS [1, 2]...

HETEROCYCLIC COMPOUNDS CONTAININGNITROGEN ARE VERY IMPORTANT BECAUSE OF THEIR BIOLOGICALLY AND PHARMACOLOGICAL ACTIVITIES [1].PHENAZONE IS A PAINKILLER, A TYPE OF MEDICATION USED TO RELIEVE PAIN. IT ALSO FUNCTIONS AS AN ANTI-INFLAMMATORY, ANTITUMOR, ANTI-MICROBIAL, ANTIVIRAL, AND ANALGESIC AND AN...

1, 3-DIPOLAR CYCLOADDITION IS AN ESSENTIAL STRATEGY FORTHE synthesis OF NATURAL PRODUCTS, ALKALOIDSAND OTHER BIOLOGICALLY ACTIVE COMPOUNDS. THE REACTION OF AZOMETHINEYLIDES WITH VARIOUS DIPOLAROPHILES RESULTS IN HIGHLY SUBSTITUTED FIVE MEMBERED NITROGEN HETEROCYCLES SUCH AS PYRROLIDINE RINGS.HENCE, AS A RESULT OF THE AFOREMENTIONED, HEREIN, WEREPORT A FACILE AND EFFICIENT synthesis OF THE NOVEL HETEROCYCLICDISPIROINDENEPYRROLIDINE RING SYSTEMS INHIGH REGIOSELECTIVITY AND DIASTEREOSELECTIVITY THROUGH ACATALYST-FREE, ONE-pot 1, 3-DIPOLAR CYCLOADDITIONREACTION OF BARBITURIC ACID DERIVATIVES, AROMATIC ALDEHYDES, NINHYDRIN AND SARCOSINEAT AMBIENT TEMPERATURE USING WATER AS SOLVENT.IN THIS REACTION, AT FIRST, THEKNOEVENAGEL CONDENSATION OF BARBITURIC ACID DERIVATIVES (OR 1, 3- INDANDIONE) WITH DIFFERENTAROMATIC ALDEHYDESWAS AFFORDED 1, 3-DIPOLAROPHILE THAT REACT WITH NON-STABILIZED AZOMETHINEYLIDE, GENERATED FROM CONDENSATIONOF SARCOSINE WITHNINHYDRIN AND THEN DECARBOXYLATION OF AMINO ACID, NOVEL HETEROCYCLIC DISPIROINDENEPYRROLIDINEWAS ACHIEVED IN HIGH YIELDS AND SHORT REACTION TIMES UNDER MILD CONDITIONS.

SOLVENTS PLAY A CENTRAL ROLE IN THESE EFFORTS: SOLVENTS ARE OFTEN THE LARGEST SOURCES OF WASTES IN CHEMICAL SYNTHESES AND PROCESSES. ELIMINATING THE USE OF SOLVENTS CAN DRAMATICALLY REDUCE THE AMOUNT OF WASTE AND VOLATILE ORGANIC COMPOUND EMISSIONS THAT ARE PRODUCED IN A PROCESS...

ISATIN HAS BEEN KNOWN FOR ABOUT 150 YEARS AND HAS BEEN RECENTLY FOUND, LIKE OXINDOLE ANDENDOGENOUS POLYFUNCTIONAL HETEROCYCLIC COMPOUNDS, TO EXHIBIT BIOLOGICAL ACTIVITY INMAMMALS…..